Faculty of Biological Science and Technology

Sadeq Vallian, Ph.D.

Department of Cell and Molecular Biology and Microbiology
University of Isfahan
Azadi square
Isfahan, Iran
Postal code: 8174673441


Area of Study

    My research has been focused on the investigation of human genome variations and their relationship with human genetic diseases. This includes the effects of genome variations on cancer progression and drug resistance. These include both coding and non-coding parts of the human genome. Polymorphisms in the genomic sequences of micro RNAs and long non-coding RNAs were specifically investigated as biomarkers related to cancer and cancer drug metabolisms and resistance. Moreover, we have been interested in the identification of the role of genomic variations in human genetic diseases.

Human Genetics Cancer Genomics Genetic Disorders, Human Genome Variation Cancer Drug Resistsnce


University of University of Texas [Texas- USA]
Postdoc. , Fellowship in Molecular Medicine, MD Anderson Cancer Center

University of University of London, UK. [London- UK]
Ph.D. , Molecular Medical Genetics, King’s College School of Medicine and Dentistry

University of Isfahan Medical Sciences [Isfahan- Iran]
M.Sc. , Clinical Biochemistry

University of Ahwaz [Ahwaz-Iran]
B.Sc. , Genetics


My research interests lie primarily in the area of Human Genetics, Cancer Genomics, Genetic Disorders, Human Genome Variation and Cancer Drug Resistsnce.


  Garavaglia,B. , Vallian, S. , Romito,LM. , Straccia,G. , Capecci, M. , & Invernizzi, F.(2022). AOPEP Variants as A Novel Cause of Recessive Dystonia: Generalized Dystonia and Dystonia-Parkinsonism. Parkinsonism & Related Disorders 97, 52-56 .

  Ebrahimi, N. , Rezanejad, H. , Asadi, MH. ,& Vallian, S.(2022). LncRNA LOC100507144 Acts as a Novel Regulator of CD44/Nanog/Sox2/miR‐302/miR‐21 axis in colorectal cancer. BioFactors 48 (1), 164-180.

  Modarres, P. , Mohamadi Farsani, F, Nekouie, AA. , & Vallian, S. (2021). Meta- Analysis of Gene Signatures and Key Pathways Indicates Suppression of JNK Pathway As A Regulator of Chemo-Resistance in AML. Scientific Reports 11 (1), 1- 16.

  Lin, YC. , Niceta, M. , Muto, V. , Vona, B. , Pagnamenta, AT. , Maroofian, R. , Beetz, C. , Vallian, S,& et al.(2021). SCUBE3 loss-of-Function Causes a Recognizable Recessive Developmental Disorder Due to Defective bone morphogenetic protein signaling. The American Journal of Human Genetics 108 (1), 115-133.

  Najafian- Najafabady, A. , Ebrahimi, N. ,& Vallian, S.(2021). rs2682818/MiR-618 is a Novel Marker Associated with an Increased Risk of Breast Cancer in the Iranian Population. Archives of Biological Sciences 73 (4), 457-463.

  Vahhab, N. , Ebrahimi, N. , Amirmahani, F. , & Vallian, S.(2021). Analysis of Polymorphic Markers Located in The HEXA Gene Region Associated With Tay-Sachs Disease. Meta Gene 26, 100772.

  Chamgordani, LE. , Ebrahimi, N. , Amirmahani, F. ,& Vallian, S.(2020). CG/CA Genotypes Represent Nnovel Markers in the NPHS2 Gene Region Associated with Nephrotic Syndrome. Journal of Genetics 99 (1), 1-7.

  Ebrahimi, N. , Moeinifar, N. , & Vallian, S.(2020). rs1542705–67,992,843-1,050,239 Represents A Novel Informative Haplotype At The SMPD1 Locus in The Iranian Population. Meta Gene 25, 100744.

  Kazemi, A. , Vallian, S. (2020). Significant Association of MiR-605 rs2043556 with Susceptibility to Breast Cancer. MicroRNA 9 (2), 133-141.

  Pourmoshir, N. , Motalleb, G. ,& Vallian, S.(2022). hsa-miR-423 rs6505162 is Associated with the Increased Risk of Breast Cancer in Isfahan Central Province of Iran. Cell Journal (Yakhteh) 22 (Suppl 1), 110.

  Esfahani, MS. , Vallian, S.(2019). A Comprehensive Study of Phenylalanine Hydroxylase Gene Mutations in The Iranian Phenylketonuria Patients. European journal of medical genetics 62 (9), 103559.

  Farsani, FM. Vallian, S. , & Ganjalikhany, MR. , Pourmoshir, N. (2019). Characterization of Novel Non-Synonymous Genomic Variants Altering drug Response of DNA Topoisomerase II Alpha. International Journal of Cancer Management 12 (4).

  Pourmoshir, N. , Farsani, FM. , & Vallian, S. (2018). Identification of Novel Estrogen Responsive Genes Differentially Expressed in High-Gradeprostate Cancer Cell Lines. European Journal of Human Genetics, 26, 976-976.

  Farsani, F. , Ganjalikhany, M. , Pourmoshir, N. , & Vallian, S. (2018). Characterization of Two Novel Non-Synonymous Genomic Variations Altering Drug Response of the DNA Topoisomerase II Alpha in the Iranian Population. European Journal of Human Genetics, 26, 679-680.

  Dehghanian, F. , Key, M. , & Vallian, S. (2018). F1174V Mutation Alters the ALK Active Conformation in Response to Crizotinib in NSCLC: Insight from Molecular Simulations. EUROPEAN JOURNAL OF HUMAN GENETICS 26, 989-990.

  Shaykholeslam Esfahani,M . , Shaykholeslam Esfahani, E. , & Vallian, S.(2018). A novel Compound-Primed Multiplex ARMS-PCR (CPMAP) for Simultaneous Detection of Common PAH gene Mutations. Metabolic Brain Disease 33 (4), 1165-1173.

  Farsani, FM. , Vallian, S.(2018). Variations Related to Resistance of Cancer Cells to Topoisomerase II Alpha Inhibitory Drugs . J Bioinform Proteom Open Access J 2 (1), 000123.

  Farsani, FM. , Ganjalikhany, MR. , & Vallian, S. (2017). Studies on Non-Synonymous Polymorphisms Altering Human DNA Topoisomerase II-alpha Interaction with Amsacrine and Mitoxantrone: An in Silico Approach. Current Cancer Drug Targets 17 (7), 657-668.

  Dehghanian, F. , Kay, M. , & Vallian, S. (2017). F1174V Mutation alters the ALK active Conformation in Response to Crizotinib in NSCLC: Insight from molecular simulations. Journal of Molecular Graphics and Modelling 75, 287-293, 2017.

  Jazaeri,A . , Vallian, S.Association of rs1738074 Polymorphism of TAGAP gene with Susceptibility to Multiple Sclerosis in the Iranian Population . Neuroscience Letters 648, 66-69, 2017.

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Teaching interests

Professional activities

Molecular Cloning

Cell Culture

Chromatin Chip Asssay

Real-Time PCR

Population Phylogenetic


Iranian Society of Human Genetics European Society of Human Genetics American Society of Human Genetics MD Anderson Associates


Human Molecular Genetics
Genetics Counseling
Population Genetics
Advanced Techniques in Genetics
The Organization of the Human Genome

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